Course description Basic Immunology

Course description

Course title
Target audience All postgraduate physicians

Medical students starting from 4th year medical school onwards

Basic information Tutorial: 8 hours provided over 6 lectures
Course provider Prof. Hatem Hamdi Eleishi, MD
Overall aims of course Immunology and molecular biology are the language of modern medicine. Physicians who lack average knowledge of those two disciplines will hardly be able to read medical journals in ten years from now. The aim of this course is to give, in a simplified manner, the fundamentals of the subject of immunology to postgraduate doctors who are interested in the subject whether they need immunology to help them with their discipline or to whether they need the basics to pursue higher levels of education in the same field.
Intended learning objectives (ILOs) By the end of the course, the candidates should be able to:

Obtain a very good comprehension of the basics of immunology

Be able to able to start reading and understanding with ease the most advanced immunology textbooks

Be able to read and comprehend the immunopathogenesis of disease without having to read immunology books first

Be able, through the many analogies provided throughout the course, to appreciate interesting philosophical links between immunology and other disciplines as history, geography, politics and logic

Curriculum of course Lecture 1: A STRUGGLE FOR SURVIVAL

Topics of lecture 1:

Broadlines versus details of immunology

Reading between the lines

Foundation of the immune system

The republic of the human body

The Neverthelesses and the Howevers

Cells that break the law

Crime scene: DO NOT ENTER

Cell apoptosis and cell necrosis

Just behind the borders of the body

Who came first: the immune system or the microbes?

Extracellular pathogens and Intracellular pathogens

Lysozyme, Phagocytosis, Opsonization

Neutrophils, Monocytes


Eosinophils, Mediator release

Complement, Mannose-binding protein, C-reactive protein

Interferon, Natural killer cells, Cytotoxicity

Innate immune system

Evolution of the specific immune system



Lecture 2: The big upgrade


Topics of lecture 2:

The Cinderella theory

B-lymphocytes T-lymphocytes

Antibodies B-cell receptors T-cell receptor

Innate immune system and Specific immune system

Antibody-dependent cytotoxicity

Simple neutralization

Fc portion of antibody

Fab portion of antibody

Feesh we tashbeeh





Lecture 3: The three orange circles

Topics of lecture 3:

Monoclonal Polyclonal

Alphabetalization VDJ rearrangement

How to get a taxi in the human body

Lymphoid ambassadors
Clonal selection

Clonal expansion

Lymphoid Police stations & Secondary lymphoid organs

Broadcast-satellite systems & Lymphocyte homing

High endothelial venules

Endothelial cells
Adhesion molecules

Lymphatic drainage

Playing dice & Somatic hypermutation

Immunoglobulin class switch




Lecture 4: The price of high tech


Topics of Lecture 4:

Pathogens and new tricks

Where we stand now

Antigen presentation

Police officers versus lay citizens

Dendritic cells

The Kitchen of the cell

Antigen processing

Fouad El Mohandes, a T-cell

We need a guide

Central tolerance

Peripheral tolerance

Major histocompatibility complex

CD4 and CD8

Cells that lost their ID



Lecture 5: Hand in hand; the old and the new technologies




Topics of Lecture 5:

Helper T cells

Different types of help

Different cassettes of vitamins

The old system is back once more with awesome abilities

The whistle of the wolf

The modern weaponry



Lecture 6: The MHC: an opinionated protein


Topics of Lecture 6:

MHC opinionated in quantity

MHC opinionated in quality

Many opinions are genetically determined

MHC and disease

Critical and non-critical peptides

Survival friendly MHCs

West Africans and malaria

MHC mutations

Gamal Hemdan and the MHC

MHC diversity

The binding groove


Teaching  methods
    1. Interactive Power Point presentations for all topics.
    2. Interactive group discussions.
    3. Course handouts
Facilities required for teaching Lecture halls

Information technology / AV aids

Assessment methods Attendance criteria: The Student needs to attend 80% of the course


Assessment tools:

A passing score in an end-of-course MCQ exam

Grading System:
Pass or fail

About the course provider Dr. Hatem Eleishi is a professor of rheumatology at Cairo University (Egypt) and deputy manager of the Continuous Medical Education Center at Faculty of Medicine, Cairo University. Eleishi graduated from Cairo University in 1990 where he then had his Masters (1994) and MD degrees (1998). He was also ECFMG certified from Philadelphia, USA in 1993.

He also has special interest in the field of medical education and personal development especially for doctors. He acquired a diploma in Medical Education from Cairo University in 2017. He is also a certified NLP (Neuro-linguistic Programming) practitioner from the United Kingdom (2010). His YouTube channel (named: Hatem Eleishi) is a collection of lectures for doctor, patient and public education.

Eleishi is also the author of several literary writings the most known of which is his novel “Tikitian Imprints” that was published in the United States by Goose River Press in 2007.